Table. Characteristics of Data Sets 1, 2, and 3.
| Characteristic | Data set 1 | Data set 2 | Data set 3 |
|---|---|---|---|
| Role in model development | Training, cross validation | External validation | External validation |
| Setting of data collection | Clinical study | Routine patient care | Routine patient care |
| Location of acquisition | Atlanta, Georgia; Portland, Oregon; Bethesda, Maryland; Durham, North Carolina | Durham, South Durham, Raleigh, North Carolina | Morrisville, Cary, North Carolina |
| SD-OCT device | Bioptigen SD-OCT | Heidelberg spectralis | Heidelberg spectralis |
| No. of patients | 316 | 53 | 48 |
| No. of eyes | 316 | 53 | 48 |
| No. of OCT volumes | 1085 | 53 | 48 |
| iAMD to iAMD, No. (%) | 721 (66.5) | 30 (56.6) | 22 (45.8) |
| iAMD to GA, No. (%) | 60 (5.5) | 23 (43.4) | 26 (54.2) |
| GA to GA, No. (%) | 304 (28.0) | 0 | 0 |
| Data labeling | Grading in certified reading center | Consensus grading by 3 ophthalmologists | Consensus grading by 3 ophthalmologists |
| Demographic characteristics | |||
| Age, mean (SD), y | 74 (8) | 83 (8) | 81 (8) |
| Sex, No. (%) | |||
| Female | 185 (59) | 32 (60) | 32 (67) |
| Male | 131 (41) | 16 (33) | 21 (40) |
| Race and ethnicity, No. (%)a | |||
| Asian | 3 (1) | 1 (2) | 0 |
| Black | 5 (2) | 1 (2) | 2 (4) |
| Hispanic/Latino | NA | 0 | 0 |
| Non-Hispanic/Latino | NA | 50 (94) | 47 (98) |
| White | 298 (95) | 50 (94) | 46 (96) |
| Other/unknowna | 10 (3) | 1 (2) | 0 |
| Declined to answer | NA | 3 (6) | 1 (2) |
Abbreviations: GA, geographic atrophy; iAMD, intermediate age-related macular degeneration; NA, not applicable; OCT, optical coherence tomography; SD-OCT, spectral-domain optical coherence tomography.
a
Race and ethnicity data were acquired via patient self-reported data as reflected in the electronic medical record. As such, the category of other reflects the record and cannot be further defined herein.