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The BP-Btz conjugate. (A) Structure and formula of BP-linker (green circle) in which modification of the BP for the linker is indicated by a black line and Btz (blue box). (B) BP-Btz (red box), which comprises the BP-linker and Btz in a form of HBr. (C) Principle of bone-targeted Btz. (D) Molecular weight and molar doses of Btz and BP-Btz used in this study.
