Table 2.
Probabilistic predictions of antibiotic mechanisms as known or novel through the fluorescence output.
| Blind Experiment | Antibiotic | Mechanism of action | P-value | Correct prediction |
|---|---|---|---|---|
|
| ||||
| Similar mechanism as the reference set | Ciprofloxacin | Interfere with bacteria DNA replication and transcription. | 0.821 | Yes |
| Ceftazidime | Inhibit bacterial cell wall biosynthesis by binding with penicillin-binding proteins. | 0.061 | Yes | |
|
| ||||
| Mechanism outside the reference set | Vancomycin | Disrupt cross-linking of bacterial peptidoglycan cell wall biosynthesis. | <0.0001 | Novel |