TABLE 1.

Artificial intelligence and circulating cfDNA in pancreatic cancer: CpG markers located within genes (intragenic; 10‐marker algorithm; 5‐fold cross‐validation).

	SVM	GLM	PAM	RF	LDA	DL
AUC 95% CI	1.0000 (0.9000–1)	1.0000 (0.9000–1)	0.9456 (0.8500–1)	0.9788 (0.9000–1)	1.0000 (0.9000–1)	1.0000 (0.9500–1)
Sensitivity	0.9000	0.9200	0.8500	0.9600	0.9555	1.0000
Specificity	0.9600	0.8800	0.9100	0.9000	0.9700	1.0000

Note: Important predictors in order: SVM: cg14224170, cg02805448, cg11148697, cg13339291, cg21466229, cg20727403, cg01430372, cg02403931, cg23178322, cg09632446. GLM: cg22712861, cg13775996, cg08035872, cg06085890, cg26607620, cg18784929, cg10275695, cg06931905, cg02484127, cg18106397. PAM: cg25773935, cg10475689, cg20967889, cg09632446, cg24531698, cg00395140, cg14224170, cg10059324, cg24273843, cg20096979. RF: cg04725405, cg06931905, cg23178322, cg09921548, cg04510815, cg05285759, cg07663722, cg27315239, cg01333650, cg21328081. LDA: cg20967889, cg25773935, cg13339291, cg14224170, cg23178322, cg17897505, cg05065507, cg24877731, cg02610227, cg10845342. DL: cg16984992, cg16590012, cgg16550438, cg07240877, cg14870958, cg01291513, cg13151361, cg21242417, cg09518293, cg00019091.

Abbreviations: DL, Deep Learning; GLM, Generalized Linear Model; LDA, Linear Discriminant Analysis; PAM, Prediction Analysis for Microarrays; RF, Random Forest; SVM, Support Vector Machine.