TABLE 3.
Least Squares Means (standard errors) of Scores Obtained on Each Symptom at Each Time Assessment and Results of Mixed Models Analyses of Variance (ANOVAs).
| ANOVAs | |||||
|---|---|---|---|---|---|
| MAG‐EPA (n = 65) | Control (n = 65) | Group | Time | Group X time | |
| Variable | M (SE) | M (SE) | F | F | F |
| HADS‐D (0–21) | 0.03 | 3.13* | 0.84 | ||
| V0 | 2.8 (0.39) | 3.2 (0.37) | |||
| V2 | 3.0 (0.33) | 2.6 (0.34) | |||
| V3 | 2.5 (0.30) | 2.2 (0.34) | |||
| V4 | 2.2 (0.33) | 2.4 (0.31) | |||
| V5 | 2.5 (0.42) | 2.3 (0.32) | |||
| PHQ‐9 (0–27) | 0.12 | 1.97 | 0.87 | ||
| V0 | 2.5 (0.41) | 2.9 (0.36) | |||
| V2 | 2.6 (0.39) | 2.8 (0.41) | |||
| V3 | 2.8 (0.52) | 2.4 (0.31) | |||
| V4 | 2.0 (0.31) | 2.4 (0.36) | |||
| V5 | 2.2 (0.37) | 2.2 (0.38) | |||
| HADS‐A (0–21) | 2.52 | 13.67**** | 1.98 | ||
| V0 | 5.0 (0.56) | 6.3 (0.44) | |||
| V2 | 4.0 (0.51) | 4.2 (0.43) | |||
| V3 | 3.5 (0.43) | 4.0 (0.34) | |||
| V4 | 3.0 (0.37) | 4.3 (0.43) | |||
| V5 | 3.3 (0.45) | 4.2 (0.43) | |||
| FCRI‐Severity (0–36) | 0.63 | 13,90**** | 1.58 | ||
| V0 | 10.5 (0.4) | 12.9 (0.83) | |||
| V2 | 10.0 (0.77) | 10.9 (0.74) | |||
| V3 | 8.9 (0.74) | 8.8 (0.73) | |||
| V4 | 8.2 (0.73) | 8.4 (0.71) | |||
| V5 | 8.4 (0.73) | 8.6 (0.73) | |||
| ISI (0–28) | 0.76 | 4.86*** | 0.35 | ||
| V0 | 6.7 (0.67) | 7.3 (0.67) | |||
| V2 | 6.2 (0.72) | 7.5 (0.68) | |||
| V3 | 5.8 (0.64) | 6.4 (0.63) | |||
| V4 | 5.3 (0.61) | 5.9 (0.60) | |||
| V5 | 6.0 (0.69) | 6.3 (0.68) | |||
| FSI‐Severity (0–30) | 0.34 | 1.51 | 0.51 | ||
| V0 | 7.9 (0.68) | 8.3 (0.68) | |||
| V2 | 7.6 (0.65) | 8.0 (0.61) | |||
| V3 | 7.4 (0.62) | 7.3 (0.60) | |||
| V4 | 6.6 (0.60) | 7.6 (0.58) | |||
| V5 | 7.6 (0.70) | 8.0 (0.68) | |||
| FSI‐Impact (0–70) | 0.00 | 1.34 | 2.43 | ||
| V0 | 9.1 (1.35) | 8.9 (1.13) | |||
| V2 | 10.0 (1.45) | 9.3 (1.14) | |||
| V3 | 9.6 (1.44) | 7.6 (0.88) | |||
| V4 | 7.0 (0.91) | 8.8 (1.28) | |||
| V5 | 8.0 (1.34) | 9.6 (1.42) | |||
| FSI‐No of days (0–7) | 1.33 | 2.48* | 0.84 | ||
| V0 | 2.0 (0.26) | 2.5 (0.25) | |||
| V2 | 1.9 (0.28) | 2.5 (0.28) | |||
| V3 | 1.9 (0.25) | 2.0 (0.25) | |||
| V4 | 1.7 (0.26) | 2.0 (0.26) | |||
| V5 | 2.1 (0.28) | 2.3 (0.28) | |||
| FSI‐Extent (0–10) | 1.05 | 0.81 | 1.18 | ||
| V0 | 2.0 (0.26) | 2.2 (0.26) | |||
| V2 | 1.7 (0.23) | 2.0 (0.21) | |||
| V3 | 1.8 (0.20) | 1.8 (0.20) | |||
| V4 | 1.7 (0.22) | 2.2 (0.21) | |||
| V5 | 1.8 (0.22) | 2.1 (0.21) | |||
| FACT‐Cog‐PCI (0–72) | 0.13 | 0.65 | 1.53 | ||
| V0 | 61.9 (1.2) | 61.8 (1.2) | |||
| V2 | 62.8 (1.3) | 61.4 (1.3) | |||
| V3 | 61.1 (1.3) | 62.0 (1.3) | |||
| V4 | 62.5 (1.3) | 61.3 (1.3) | |||
| V5 | 63.0 (1.3) | 61.9 (1.3) | |||
| FACT‐Cog‐Others (0–16) | 0.06 | 0.52 | 1.24 | ||
| V0 | 15.6 (0.20) | 15.4 (0.18) | |||
| V2 | 15.5 (0.15) | 15.5 (0.18) | |||
| V3 | 15.5 (0.16) | 15.7 (0.11) | |||
| V4 | 15.7 (0.11) | 15.5 (0.20) | |||
| V5 | 15.7 (0.12) | 15.6 (0.15) | |||
| FACT‐Cog‐PCA (0–28) | 0.01 | 0.61 | 0.15 | ||
| V0 | 22.7 (0.86) | 22.5 (0.85) | |||
| V2 | 21.7 (0.95) | 22.2 (1.03) | |||
| V3 | 22.6 (0.91) | 22.7 (0.94) | |||
| V4 | 23.1 (0.81) | 22.5 (0.92) | |||
| V5 | 23.2 (0.82) | 22.9 (0.91) | |||
| FACT‐Cog‐Impact (0–16) | 0.03 | 3.03* | 3.39* | ||
| V0 | 14.2 (0.40) | 14.0 (0.40) | |||
| V2 | 13.5 (0.45) | 13.9 (0.42) | |||
| V3 | 14.4 (0.28) | 15.0 (0.27) | |||
| V4 | 14.8 (0.28) | 14.4 (0.28) | |||
| V5 | 14.6 (0.36) | 14.5 (0.36) |
Abbreviations: Extent, how much of the day they felt fatigued; FACT‐Cog, Functional Assessment of Cancer Therapy—Cognitive Function; FCRI, Fear of Cancer Recurrence Inventory; FSI, Fatigue Symptom Inventory; HADS‐A, anxiety subscale of the Hospital Anxiety and Depression Scale; HADS‐D, depression subscale of the Hospital Anxiety and Depression Scale; Impact, impact on quality of life; ISI, Insomnia Severity Index; Others, comments from others; PCA, perceived cognitive abilities; PCI, perceived cognitive impairment; PHQ‐9, Patient Health Questionnaire‐9; V0, baseline; V2, 3 months; V3, 6 months; V4, 9 months; V5, 12 months.
Note: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.