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. Author manuscript; available in PMC: 2023 Oct 20.
Published in final edited form as: Antiviral Res. 2019 Feb 12;164:70–80. doi: 10.1016/j.antiviral.2019.02.005

Figure 1. Representative replication inhibition efficacy and cytotoxicity assays.

Figure 1.

Replication inhibition by representative HIDs and HPDs was measured against an HBV genotype D isolate in HepDES19 cells using a strand preferential q-PCR assay. EC50 values were calculated based on the decline of the positive-polarity DNA strand relative to the DMSO vehicle treated controls. Positive-polarity DNAs are in black; negative-polarity DNAs are in grey. EC50 values are the average of three experiments ± one standard deviation. Cytotoxicity was measured by MTS assay and CC50 values are the averages of three experiments ± one standard deviation.