Table 1.

PTHR1 and PTHR2 Activation for PTH(1-34) and α/β/γ-Analogues 1 and 2.

	PTHR1 cAMP Production				PTHR2 cAMP Production
Peptide	pEC50	EC50 (nM)	EC50 relative	% Max	pEC50	EC50 (nM)	EC50 relative	% Max
PTH(1-34)	9.2 ± 0.1	0.58	1	102 ± 4	9.2 ± 0.05	0.69	1	100 ± 2
1	8.6 ± 0.1	2.3	4	116 ± 6	7.5 ± 0.07	29	42	76 ± 3
2	8.2 ± 0.1	6.2	11	119 ± 7	6.6 ± 0.2	280	406	11 ± 2

For PTHR1 activation, measured via stimulation of intracellular cAMP, pEC₅₀, EC₅₀ and maximal response (% Max) values were derived from 4 independent experiments. For PTHR2 activation, pEC₅₀, EC₅₀ and % Max represent the average of ≥4 independent experiments. pEC₅₀ indicates the negative logarithm of the half-maximal effective concentration (EC₅₀). EC₅₀ relative indicates cAMP potency normalized to PTH(1-34) by the quotient (α/β/γ-analogue/PTH(1-34)). pEC₅₀ and % Max uncertainties are expressed as SEM.