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NLuc-GLP-1R Affinity for GLP-1(7-36) and α/β/γ-Analogues 7 and 8.
| NLuc-GLP-1R Affinity | |||
|---|---|---|---|
| Peptide | pIC50 | IC50 (nM) | IC50 relative |
| GLP-1(7-36) | 7.3 ± 0.04 | 54 | 1 |
| 7 | 6.7 ± 0.05 | 200 | 4 |
| 8 | 6.1 ± 0.05 | 850 | 16 |
Competition NLuc-GLP-1R pIC50 and IC50 values are the average of ≥3 independent experiments. pIC50 indicates the negative logarithm of the half-maximal inhibitory concentration (IC50). IC50 relative indicates binding affinity normalized to GLP-1(7-36) by the quotient (α/β/γ-analogue/GLP-1(7-36)).
