Table 3.
Association between the primary outcome and circulating microRNAs
| Subgroup | miRNA | Univariable model | Model 1a | Model 2b | Model 3c | ||||
|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| Overall | miR-133a-3p | 0.93 (0.89–0.96) | < 0.0001 | 0.93 (0.90–0.97) | 0.0004 | 0.94 (0.90–0.97) | 0.001 | 0.96 (0.92–1.00) | 0.061 |
| miR-501-3p | 0.97 (0.90–1.04) | 0.39 | 0.98 (0.91–1.05) | 0.57 | 0.92 (0.85–0.99) | 0.034 | 0.96 (0.89–1.04) | 0.34 | |
| Control | miR-133a-3p | 0.91 (0.86–0.96) | 0.002 | 0.92 (0.86–0.97) | 0.004 | 0.92 (0.86–0.98) | 0.008 | 0.95 (0.89–1.01) | 0.12 |
| miR-501-3p | 0.92 (0.81–1.04) | 0.18 | 0.92 (0.82–1.04) | 0.20 | 0.89 (0.78–1.02) | 0.086 | 0.91 (0.79–1.04) | 0.15 | |
| ASV | miR-133a-3p | 0.94 (0.89–0.99) | 0.013 | 0.94 (0.90–0.99) | 0.023 | 0.94 (0.90–0.99) | 0.026 | 0.96 (0.91–1.01) | 0.13 |
| miR-501-3p | 1.00 (0.91–1.10) | 0.95 | 1.01 (0.92–1.11) | 0.83 | 0.93 (0.84–1.03) | 0.15 | 0.98 (0.88–1.09) | 0.73 | |
Bold values indicate the statistically significant results
HR hazard ratio, CI confidence interval
aModel 1 included adaptive-servo ventilation (ASV), age and sex
bModel 2 included variables of model 1 and systolic blood pressure (SBP) < 120 mmHg, diabetes, diuretic, atrial fibrillation, cardiac device and 6-min walk distance
cModel 3 included variables of model 2 and log (NT-proBNP)