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. 2023 Oct 19;21:741. doi: 10.1186/s12967-023-04578-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — ALKBH5 regulates lipid metabolism of pNENs by modulating PI3K/Akt/mTOR signaling pathway. A KEGG enrichment barplot based on ALKBH5 knockdown and scramble RNA-seq data. B, C Expression levels of PI3K/Akt/mTOR signaling pathway related proteins as determined by western blotting after ALKBH5 knockdown and over-expression in pNENs cells. D Expression levels of PI3K/Akt/mTOR signaling pathway related proteins as determined by western blotting in ALKBH5 over-expression cells with or without FABP5 knockdown. E, F LDs (lipid droplets) were detected using Nile red in QGP-1 cells from the indicated groups, along with the results of relative fluorescence intensity, magnification: ×200. G–I The cellular content of free fatty acids (FFA), triglycerides, and total cholesterol were detected in QGP-1 cells from the indicated groups. *p < 0.01, **p < 0.01, ***p < 0.001