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. 2023 Oct 19;25:126. doi: 10.1186/s13058-023-01728-y

Table 1.

Sample, molecular characteristics, function, and reference of cell subpopulations

Cell subpopulations Sample Molecular characteristics Function References
ARTN + L1CAM + epi_tum1 Primary Cancer ARTN, L1CAM Promotes angiogenesis and metastasis Shi et al
HMGA1-high Cancer Stem Cell Axillary lymph HMGA1 Promote lymph node metastasis Nakayama et al
Early-disseminated Cancer Cell Axillary lymph COX6C, DHRS2 Metastasis of energy metabolism Liu et al
CXCL14 + Cancer Cell Lymph node CXCL14, KAT6B Evade immune surveillance during metastasis Xu et al
Osteoclast-like giant Cell Lymph node MMP9, CST3, CD68 Promote the growth of metastatic cells Xu et al
Lung L3 Cancer Stem Cell Lung ALDH1A1, ABCG2 Promote lung metastasis Xu et al
TREM2 + Macrophage Bone marrow TREM2, CD68 Promote bone marrow metastasis Molgora et al
Dormant Cancer Cell Tissue CFH, GAS6 Promotes bone/cerebrospinal fluid metastasis Bidard et al