Table 1.
B vitamin metabolomic biomarker results from the TwinsUK and KORA F4 epigenetic association meta-analysis (Bonferroni-adj. p < 0.05, HetISq < 75 and HetPVal ≥ 0.05; n = 2182)
| DMP | UCSC gene(s) (± 10 kb) |
Compound name |
Effect size | SE | p value | Direction* | HetISq | HetPVal |
|---|---|---|---|---|---|---|---|---|
| cg20732160 ( ~) | PFKFB4/UCN2 | Pipecolate | − 2.91E−02 | 4.32 E−03 | 1.68 E−11 | – – | 0.00 | 0.945 |
| cg10589813 (@) | CEBPB | Pipecolate | − 2.93 E−02 | 4.43 E−03 | 3.49 E−11 | – – | 0.00 | 0.825 |
| cg18120259 ( ~) | LOC100132354 | Pipecolate | − 2.67 E−02 | 4.36 E−03 | 9.18 E−10 | – – | 0.00 | 0.510 |
| cg11800635 ( ~) | LOXL3/DOK1/M1AP | Pipecolate | − 3.26 E−02 | 5.61 E−03 | 6.35 E−09 | – – | 0.00 | 0.385 |
| cg08616943 (@) |
LOC646329/MIR29A/ MIR29B1 |
Pipecolate | − 2.18 E−02 | 3.76 E−03 | 6.94 E−09 | – – | 0.00 | 0.942 |
| cg03523740 (^) | KPNA6/TXLNA | Pipecolate | − 1.69 E−02 | 2.97 E−03 | 1.14 E−08 | – – | 0.00 | 0.708 |
| cg12054453 ( ~) |
VMP1/MIR21/ DM119512/U6 |
Pipecolate | − 6.60 E−02 | 1.18 E−02 | 2.26 E−08 | – – | 46.60 | 0.171 |
| cg26841068 ($) | PRELP/OPTC | Pipecolate | − 2.26 E−02 | 4.17 E−03 | 5.66 E−08 | – – | 0.00 | 0.587 |
| cg13442969 (~ , #) | DYRK2 | Pipecolate | − 2.87 E−02 | 5.34 E−03 | 7.84 E−08 | – – | 57.50 | 0.125 |
| cg27180443 (^) | SCARB1 | Pipecolate | − 1.72 E−02 | 3.23 E−03 | 1.05 E−07 | – – | 0.00 | 0.570 |
| cg02711608 (~ , #, %) | SLC1A5 | Pyridoxate | − 3.76 E−02 | 6.23 E−03 | 1.63 E−09 | – – | 2.30 | 0.312 |
| cg06690548 ( ~) | SLC7A11 | Pyridoxate | − 7.33 E−02 | 1.30 E−02 | 1.65 E−08 | – – | 71.50 | 0.061 |
| cg22304262 (~ , #) | SLC1A5 | Pyridoxate | − 4.10 E−02 | 7.64 E−03 | 8.27 E−08 | – – | 0.00 | 0.444 |
| cg03440556 ( ~) | SCD | DHA | 9.25 E−02 | 1.57 E−02 | 4.07 E−09 | + + | 0.00 | 0.366 |
Location: ~ gene body, ^ TSS1500, $ 3’UTR, # 5’UTR, % 1st exon, @ intergenic region
*Directions of effect in TwinsUK and KORA, respectively