Table 1.

Histopathologic criteria for the diagnosis of diffuse nesidioblastosis in adults (recently known as ANHH) proposed by Anlauf et al.

MAJOR CRITERIA	MINOR CRITERIA
Exclusion of an insulinoma by macroscopic, microscopic, and immunohistochemical examinations	Irregular shape and occasional enlargement of islets
Multiple β-cells with an enlarged and hyperchromatic nucleus and abundant clear cytoplasm	Increased number of islets
Islets with normal spatial distribution of the various cell types	Lobulated islet structure
No proliferative activity of endocrine cells	Macronucleoli in β-cells