Fig. 3.

The four tRFs modification patterns and their potential enzymes. (A) Examples of tRNA structures of tRF-19-R118LOJX, tRF-19-6SM83OJX, tRF-30-87R8WP9N1EWJ and tRF-30-PNR8YP9LON4V were depicted. The red nucleotides indicate the four tRFs. The yellow and green arrowheads show the positions of m¹G9 and m²G6 modifications, respectively. The relative mRNA expressions of Dicer (B), TRMT112 (C) and TRMT10A (D) in the II (n = 291), III (n = 334) and IV (n = 388) grades of glioma in CGGA dataset. Data represents mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001