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. 2023 Oct 20;23:1015. doi: 10.1186/s12885-023-11532-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — The upregulated target genes of tRF-19-R118LOJX promote tumorigenesis and predict poor overall survival of GBM patients. (A) Venn diagram for overlapped DEGs of CGGA between LGG and GBM, the target genes of tRF-19-R118LOJX enriched by blood vessel development and all target genes of tRF-19-R118LOJX. (B) Volcano plot of DEGs of CGGA and the differentially expressed target genes of tRF-19-R118LOJX (indicated using data tag) for LGG vs. GBM of CGGA. The red points indicate upregulated genes (n = 17), and the blue points indicate downregulated genes (n = 9) with absolute fold change values greater than 2 being statistically significant. Non-differentially expressed genes are indicated in gray. (C) KEGG mapping of proteoglycans in cancer is the most enriched pathway of the differentially expressed target genes of tRF-19-R118LOJX. Orange-marked nodes correspond to target genes from tRF-19-R118LOJX. (D) Overall survival analysis of the upregulated target genes of tRF-19-R118LOJX in GBM vs. LGG.