Table 2.

Published examples of systems analysis methods being used to study implementation mechanisms

Systems analysis method	Definition	Usage example	References for more information
Agent-based modeling	Computational modeling that simulates actions and interactions of actors (e.g., individuals, groups, and/or organizations) within a system, as well as system behavior and outcomes emerging from the interactions of these actors and each actor’s assigned characteristics [30]	Testing the hypothesis that actors strongly identifying with their organizations is a mechanism that drives intraorganizational behavioral divergence and network polarization for the implementation of evidence-based practices [31]	[32, 33]
Causal pathway diagramming	Visual representation of causal, dynamic interrelations among variables and outcomes of interest in a given context [4]	Specifying the mechanisms of action of implementation strategies used to improve acute stroke treatment practices [34]	[35, 36]
Participatory system dynamics	Use of a participatory epistemology to develop and integrate modeling of complex systems to support decisions that are currently least supported and to empower those who are typically the least empowered; models therefore are developed, reviewed, and acted upon in partnership with individuals who are affecting and affected by the system being modeled [37]	Determining the mechanisms through which past actions taken either enabled or constrained clinical guidelines implementation [38]	[25, 39]
Process evaluation	Assessment and documentation of the developed, planned, and delivered implementation strategy [40]	Ascertaining what characteristics of front-line staff and leadership served as mechanisms for hand hygiene improvement [41]	[42–44]
Realist evaluation	Generation of a theory-driven and practice-informed model that connects context, mechanisms, and outcome patterns [45]	Studying contextual factors and causal mechanisms that enabled or hindered evidence-based interventions’ sustainability [46]	[47, 48]
Ripple effects mapping	Participatory evaluation that generates a visualization of causes and their cascaded effects radiating from each cause, along with participants’ first-hand experiences [49]	Establishing context-mechanism-outcome configurations based on mixed-methods data for an intervention to increase physical activity [50]	[51, 52]
Simulation modeling	Creation and analysis of a computational model of a system to replicate and anticipate the system’s real-world behavior [53]; of note, some of the other listed methods (e.g., agent-based modeling and participatory system dynamics) are subsumed under this method	Articulating and refining implementation actors’ articulation of hypotheses regarding causal mechanisms of the intervention and implementation strategies [24]	[29]
Structural equation modeling	Mathematical representation of a phenomenon to investigate aspects of the phenomenon that are statistically and/or causally related to one another and to the phenomenon [54]	Examining the mediators of hospitals’ escalation prevention potential as mechanisms for successful electronic health record implementation [55]	[56–58]