Table 4.

The adjusted odds ratio (95% confidence interval) describing the annual variation in susceptibility of Pasteurella multocida (PM) isolates to quinolones (enrofloxacin and marbofloxacin), tetracyclines (doxycycline and oxytetracycline), beta-lactams (ceftiofur and amoxicillin), phenicols (florfenicol), sulfonamides (sulfamethoxazol/trimethoprim), pleuromutilins (tiamulin) and macrolides (tilmicosin, tulathromycin and tildipirosin) using the logistic regression model

Drug	Enrofloxacin	Marbofloxacin	Doxycycline	Oxytetracycline
Year	NS	NS	T (p = 0.08)	S (p = 0.018)
20 vs. 19	NS	NS	NS	NS
21 vs. 20	NS	NS	NS	NS
22 vs. 21	NS	NS	NS	S- 2.1 (1.3–3.3)
Drug	Ceftiofur	Amoxicillin	Florfenicol	Sulfamethoxazol/trimethoprim
Year	NS	NS	NS	S (p = 0.008)
20 vs. 19	NS	NS	NS	S- 4.3 (1.5–11.7)
21 vs. 20	NS	NS	NS	NS
22 vs. 21	NS	NS	NS	NS
Drug	Tiamulin	Tilmicosin	Tulathromycin	Tildipirosin
Year	S (p = 0.01)	NS	NS	NS
20 vs. 19	NS	NS	NS	NS
21 vs. 20	S- 0.58 (0.34–0.99)	NS	NS	NS
22 vs. 21	S- 2.15 (1.36–3.38)	NS	NS	NS

S means significant (p < 0.05). OR is significant if the confidence interval 95% does not contain the 1 value

NS means not significant (p > 0.05)

T means statistical tendency