Table 1.

Natural products as inducer of GRP78 in cervical cancer cells

Nature products	Pharmacological effect	Cervical cells
Dicerandrol from endophytic fungus, Phomopsis sp. Hesperidin from citrus fruits	G2/Mell cycle arrest Induce apoptosis induce ROS G0/G1cycle arrest cyclinD1 cyclinE1 inhibit	HeLa cells [91]
	Activate Caspase-3 induce apoptosis	HeLa cells [92]
Sesamin from sesamum indicun	Induce apoptosis Caspase-2,GADD153, RE1α, -IRE1α, NK p-JNK Induce autophagy LC3I/II, Beclin-1	HeLa cells [62] HeLa cells [93]
Isoliquiritigenin From iquorice	Induce ROS Induce apoptosis Caspase-12
3alpha,23-sopropylidenedioxyolean-12-en-27-oic acid (IPA)	Induce apoptosis Caspase-3,8,9 Mui-calpain GADD153	HeLa Cells [94]
Genistein from soybeans	Induce apoptosis Caspase-3 CHOP	HeLa cells [95]
Gambogic acid from Garcinia hanburyi	Induce apoptosis Caspas3,8,9, JNK	HeLa cells [96]