Table 3.

Patients who were transfused. None had sickle cell trait or sickle cell disease

Day of blood transfusion	Age	Sex	Enlarged spleen	D0 parasitaemia (/µL)	G6PD status	Thalassaemia statusa	SLDPQ/placebo	ACT	D0 Hb (g/dL)	Hb when transfused day (g/dL)	Fractional fall	Develop severe malaria	Parasitaemia when transfused/µL)
D0	3	Male	N	0b	DEF	αα/αα	SLDPQ	DHAPP	6.5	4.8	− 0.26	Y—severe anaemia	0
D0	3	Male	Y	0b	NOR	-α/αα	Placebo	AL	6.4	4.9	− 0.23	Y—severe anaemia	0
D1	3	Male	N	28,786	NOR	-α/αα	SLDPQ	DHAPP	11.4	4.8	− 0.58	Y—prostration and severe anaemia	98
D1	1	Male	N	660,970	DEF	αα/αα	Placebo	AL	8.3	5.9	− 0.29	Y—unrousable coma	586,678
D2	1	Male	N	250,536	NOR	αα/αα	SLDPQ	DHAPP	8	4.6	− 0.43	N	0
D2	2	Female	Y	579,443	NOR	-α/αα	SLDPQ	AL	6.8	4.8	− 0.29	N	203
D2	6	Female	Y	211,430	NOR	αα/αα	Placebo	AL	9.4	4.9	− 0.48	N	0
D4	9	Female	Y	497,818	DEF	αα/αα	Placebo	AL	6.5	6.5	0.00	N	0
D4	4	Male	N	260	DEF	αα/αα	SLDPQ	AL	6.5	5.3 (1 day before)	− 0.18	Y—prostration and severe anaemia	0 (1 day before)
D5	4	Male	Y	5860	NOR	-α/αα	Placebo	DHAPP	9.8	6.7	− 0.32	N	0
D31	9	Female	N	219,637	NOR	-α/αα	SLDPQ	DHAPP	13.3	9.6 (4 days before)	− 0.28	Y—prostration, haemoglobinuria, and severe anaemia	1908 (4 days before)

^aαα/αα normal haemoglobin type, -α/αα heterozygous alpha thalassaemia (silent carrier), -α/-α homozygous alpha thalassaemia (thalassaemia trait)

^bMalaria slide negative but rapid test positive