Table 3.

SYRCLE risk of bias assessment for included studies

References	Selection bias			Performance bias		Detection bias		Attrition bias	Reporting bias	Free from other bias?
	Random sequence generation	Groups similar at baseline	Allocation concealment	Animals random housing	Blinding of caregivers and/or examiners	Random outcome assessment	Blinding of outcome assessor	Incomplete outcome data addressed	Free from selective outcome reporting
[61]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	No
[54]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	No
[63]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes
[62]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes
[43]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes
[44]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[64]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[65]	Unclear	Unclear	Yes	Unclear	Unclear	Yes	Unclear	Yes	Yes	Yes
[66]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[67]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes
[41]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[42]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[58]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes
[68]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[57]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes
[59]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes
[47]	Yes	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes
[48]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	No
[70]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[37]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[71]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes
[60]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	No
[72]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[73]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[74]	Yes	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[45]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[75]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[53]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes
[76]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[77]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[52]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes
[56]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[40]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[49]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	No
[50]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[46]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[51]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[39]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[38]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes
[55]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes