Table 6.
Comparison between genotypes (CXCL12 rs2839693) according to demographic data, comorbidity, and symptoms
| CXCL12 rs2839693 | ||||||||
|---|---|---|---|---|---|---|---|---|
|
CC (n = 209) |
CT + TT (n = 91) |
OR (95%CI) | P value* |
CC (n = 209) |
CT (n = 84) |
TT (n = 7) |
P value* | |
| No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | ||||
| Age (years) | ||||||||
| ≤ 65 | 101(48.3) | 43(47.3) |
1.04 (0.64–1.71) |
&0.900 | 101(48.3) | 42(50.0) | 1(14.3) | &0.189 |
| > 65 | 108(51.7) | 48(52.7) | 108(51.7) | 42(50.0) | 6(85.7) | |||
| Median (Range) |
66 (36–93) |
70 (47–82) |
------ | §0.221 |
66 (36–93) |
70 (47–82) |
62 (58–68) |
§0.042* |
| Sex | ||||||||
| Male | 113(54.1) | 56(61.5) |
0.74 (0.45–1.22) |
&0.256 | 113(54.1) | 52(61.9) | 4(57.1) | &0.473 |
| Female | 96(45.9) | 35(38.5) | 96(45.9) | 32(38.1) | 3(42.9) | |||
| Smoking | ||||||||
| No | 131(62.7) | 51(56.0) |
1.32 (0.80–2.17) |
&0.305 | 131(62.7) | 47(56.0) |
4 (57.1) |
&0.556 |
| Yes | 78(37.3) | 40(44.0) | 78(37.3) | 37(44.0) | 3(42.9) | |||
| Vaccination(AstraZeneca or Pfizer) | ||||||||
| No | 62(29.7) | 30(33.0) |
0.86 (0.51–1.46) |
&0.588 | 62(29.7) | 27(32.1) | 3(2.9) | &0.714 |
| Yes | 147(70.3) | 61(67.0) | 147(70.3) |
57 (67.9) |
4(57.1) | |||
| Co-morbid diseases | ||||||||
| None | 69(33.0) | 22(24.2) |
0.65 (0.37–1.13) |
&0.135 | 69(33.0) | 22(26.2) | 0(0) | &0.109 |
| Hypertension | 76(36.4) | 31(34.1) |
0.90 (0.54–1.52) |
&0.793 | 76(36.4) | 29(34.5) |
2 (28.6) |
&0.884 |
| Liver disease | 10(4.8) | 7(7.7) |
1.66 (0.61–4.50) |
&0.415 | 10(4.8) | 6(7.1) | 1(14.3) | &0.445 |
| Renal disease | 23(11.0) | 16(17.6) |
1.73 (0.86–3.45) |
&0.136 | 23(11.0) | 14(16.7) | 2(28.6) | &0.198 |
| DM | 52(24.9) | 26(28.6) |
1.21 (0.70–2.10) |
&0.567 | 52(24.9) | 23(27.4) | 3(42.9) | &0.534 |
| Thyroid disease | 7(3.3) | 5(5.5) |
1.68 (0.52–5.43) |
&0.522 | 7(3.3) | 5(6.0) | 0(0) | &0.508 |
| Heart disease | 8(3.8) | 5(5.5) |
1.46 (0.47–4.59) |
&0.543 | 8(3.8) | 5(6.0) | 0(0) | &0.514 |
| Symptoms | ||||||||
| Fever | 49(23.4) | 24(26.4) |
1.17 (0.66–2.06) |
&0.661 | 49(23.4) | 20(23.8) | 4(57.1) | &0.123 |
| Sore throat | 82(39.2) | 28(30.8) |
0.69 (0.41–1.16) |
&0.193 | 82(39.2) | 26(31.0) | 2(28.6) | &0.373 |
| Dry cough | 116(55.5) | 45(49.5) |
0.78 (0.48–1.28) |
&0.378 | 116(55.5) | 42(50.0) | 3(42.9) | &0.587 |
| Headache | 46(22.0) | 23(25.3) |
1.19 (0.67–2.13) |
&0.553 | 46(22.0) | 21(25.0) | 2(28.6) | &0.807 |
| Dyspnea | 83(39.7) | 61(67.0) |
3.09 (1.84–5.18) |
& < 0.001* | 83(39.7) | 54(64.3) | 7(100) | & < 0.001* |
| Diarrhea | 17(8.1) | 4(4.4) |
0.52 (0.17–1.59) |
&0.327 | 17(8.1) | 3(3.6) | 1(14.3) | &0.286 |
| Myalgia | 82(39.2) | 41(45.1) |
1.27 (0.77–2.09) |
&0.373 | 82(39.2) | 39(46.4) | 2(28.6) | &0.419 |
| Fatigue | 117(56.0) | 48(52.7) |
0.88 (0.54–1.44) |
&0.616 | 117(56.0) | 45(53.6) | 3(42.9) | &0.753 |
| Nausea | 31(14.8) | 13(14.3) |
0.96 (0.48–1.93) |
&1.000 | 31(14.8) | 11(13.1) | 2(28.6) | &0.535 |
| Vomiting | 9(4.3) | 6(6.6) |
1.57 (0.54–4.54) |
&0.399 | 9(4.3) | 4(4.8) | 2(28.6) | &0.015* |
| Anosmia | 63(30.1) | 22(24.2) |
0.74 (0.42–1.30) |
&0.331 | 63(30.1) | 21(25.0) | 1(14.3) | &0.478 |
| Gustatory dysfunction | 53(25.4) | 16(17.6) |
0.63 (0.34–1.17) |
&0.179 | 53(25.4) | 15(17.9) | 1(14.3) | &0.331 |
| Dysarthria | 4(1.9) | 5(5.5) |
2.98 (0.78–11.4) |
&0.136 | 4(1.9) | 3(3.6) | 2(28.6) | & < 0.001* |
| Clinical course | ||||||||
| Mild or moderate illness | 126(60.3) | 30(33.0) |
3.09 (1.84–5.18) |
& < 0.001* | 126(60.3) | 30(35.7) | 0(0) | & < 0.001* |
| Severe or critical illness | 83(39.7) | 61(67.0) | 83(39.7) | 54(64.3) | 7(100) | |||
§Mann Whitney test. &Fisher's Exact test. P values represent statistical significance < 0.05
*Significant. OR Odds ratio. CI confidence interval. DM Diabetes Mellitus