Table 8.
Comparison between genotypes (CXCL12 rs2839693) according to treatment and outcomes
| CXCL12 rs2839693 | ||||||||
|---|---|---|---|---|---|---|---|---|
|
CC (n = 209) |
CT + TT (n = 91) |
OR (95%CI) | P value* |
CC (n = 209) |
CT (n = 84) |
TT (n = 7) |
P value* | |
| No. (%) | No. (%) | No. (%) | No.(%) | No.(%) | ||||
| Antibiotic | 203(97.1) | 85(93.4) | 0.42(0.13–1.34) | &0.196 | 203(97.1) | 78(92.9) | 7(100) | &0.207 |
| Antifungal | 12(5.7) | 6(6.6) | 1.16(0.42–3.19) | &0.794 | 12(5.7) | 6(7.1) | 0(0) | &0.717 |
| Antiviral | 155(74.2) | 77(84.6) | 1.92(1.00–3.66) | &0.052 | 155(74.2) | 71(84.5) | 6(85.7) | &0.138 |
| Glucocorticoids | 116(55.5) | 60(65.9) | 1.55(0.93–2.59) | 0.099 | 116(55.5) | 55(65.5) | 5(71.4) | &0.230 |
| Clexane | 57(27.3) | 35(38.5) | 1.67(0.99–2.81) | &0.058 | 57(27.3) | 30(35.7) | 5(71.4) | &0.022* |
| Oxygen therapy | ||||||||
| None | 64(30.6) | 9(9.9) | 0.25(0.12–0.53) | & < 0.001* | 64(30.6) | 9(10.7) | 0(0) | & < 0.001* |
| Nasal cannula | 43(20.6) | 35(38.5) | 2.41(1.41–4.14) | &0.002* | 43(20.6) | 29(34.5) | 6(85.7) | & < 0.001* |
| Mask oxygen | 96(45.9) | 54(59.3) | 1.72(1.04–2.83) | &0.044* | 96(45.9) | 50(59.5) | 4(57.1) | &0.102 |
| Invasive mechanical ventilation | 8(3.8) | 10(11.0) | 3.10(1.18–8.14) | &0.031* | 8(3.8) | 10(11.9) | 0(0) | &0.025* |
| Outcomes | ||||||||
| Home management | 65(31.1) | 13(14.3) | 0.37(0.19–0.71) | &0.002* | 65(31.1) | 13(15.5) | 0(0) | &0.006* |
| Hospitalization without ICU | 61(29.2) | 17(18.70 | 0.56(0.30–1.02) | &0.063 | 61(29.2) | 17(20.2) | 0(0) | &0.082 |
| ICU | 83(39.7) | 61(67.0) | 3.09(1.84–5.18) | & < 0.001* | 83(39.7) | 54(64.3) | 7(100) | & < 0.001* |
| Death | 21(10.0) | 18(19.8) | 2.21(1.11–4.38) | &0.026* | 21(10.0) | 13(15.5) | 5(71.4) | & < 0.001* |
| Duration of ICU stay (days) | ||||||||
| Median( Range) | 8.00(1–13) | 7.00(1–13) | ------ | §0.284 | 8.00(1–13) | 6.50(1–13) | 9.00(1–12) | §0.159 |
| Duration of in-hospital stay (days) | ||||||||
| Median(Range) | 7.50(1–15) | 7.00(1–15) | ------ | §0.856 | 7.50(1–15) | 7.00(1–15) | 12.00(6–15) | §0.035* |
| Duration of recovery (days) | ||||||||
| Median (Range) | 18.00(2–48) | 15.00(2–48) | ------ | §0.703 | 18.00(2–48) | 15.00(2–48) | 23.50(2–44) | §0.930 |
§Mann Whitney test
&Fisher's Exact test. p values represent statistical significance < 0.05
*Significant. OR Odds ratio. CI confidence interval. ICU Intensive care unit