Table 2.
Summary of Costs per Procedure, DALYs Averted, Cost per DALY Averted, and Cost-Effectiveness Thresholds.
| Article | NGO (Center vs mission based) | Country(ies)/Year | Cost per cleft lip and cleft palate procedure (USD, 2020) | Cleft lip, cleft palate or both* | DALYs averted per patient (with 3% discounting, 2020) | Cost per DALY averted (USD, 2020) | World Health Organization threshold (1 times the GDP per capita) | 51% GDP per capita cost-effectiveness threshold | 1% GDP per capita cost-effectiveness threshold |
|---|---|---|---|---|---|---|---|---|---|
| Alkire et al. (2011) 10 | (Not specified) | Subsaharan Africa, 2008 | 316.27 | Both | 5.35 | 59.13 | 1572.61 | 801.72 | 8.02 |
| Corlew (2010)14 | Interplast, now ReSurge (Center-Based) | Nepal, 2005 | 513.40 | Cleft lip | 4.04 | 126.96 | 1025.80 | 523.16 | 5.23 |
| Cleft palate | 10.59 | 48.48 | |||||||
| Magee et al. (2010) 19 | Operation Smile (Mission-Based) | Vietnam,2008 | 850.40 | Both | 8.18 | 100.32 | 2563.81 | 1307.54 | 13.08 |
| Nicaragua, 2008 | 816.03 | Both | 6.70 | 85.42 | 2028.90 | 1034.74 | 10.35 | ||
| Kenya, 2008 | 658.37 | Both | 3.16 | 146.30 | 1710.51 | 872.36 | 8.72 | ||
| Russia, 2008 | 685.40 | Both | 9.46 | 50.84 | 11,888.72 | 6063.25 | 60.63 | ||
| Moon et al. (2012) 20 | Smile for Children (Mission-Based) | Vietnam, 2007 | 511.38 | Both | Not listed | 96.63 | 2563.81 | 1307.54 | 25.64 |
| Vietnam, 2008 | 519.39 | Both | Not listed | 113.35 | |||||
| Vietnam, 2009 | 366.73 | Both | Not listed | 70.37 | |||||
| Vietnam, 2010 | 426.33 | Both | Not listed | 89.26 | |||||
| Hughes et al. (2012) 18 | Hands Across the World (Mission-based) | Ecuador, 2011 | Not listed | Both | 8.3 | Not Listed | |||
| Poenaru (2013) 22 | Smile Train (Center-based) | 79 Countries, 2010 | 482.54 | Both | 4.32 | 111.81 | 1905.77 | 971.94 | 19.06 |
| Rattray et al. (2013) 24 | Children's Surgical center (Center-based) | Cambodia, 2012 | Not listed | Not listed | Not listed | 102.67 | 1512.13 | 771.18 | 7.71 |
| Hackenberg et al. (2015) 16 | Operation Smile Guwahati Cleft Care Missions (Both) | India, Medical Missions, 2012 | 1421.93 | Both | 4.74 | 239.21 | 2015.59 | 1027.95 | 10.28 |
| India, Care Center, 2012 | 2324.70 | Both | 4.74 | 440.20 | |||||
| Poenaru et al. (2016) 23 | Smile Train (Center-Based) | 83 Countries | 443.89 | Both | 2.49 | 178.48 | 1905.77 | 971.94 | 9.72 |
| Hamze et al. (2017) 17 | Smile Train and AMREF (Center-Based) | Eastern and Central Africa, 2014 | 400.25 | Cleft lip | 4.19 | 95.58 | 1572.61 | 802.03 | 15.73 |
| Cleft palate | 10.40 | 38.48 | |||||||
| Both | 4.67 | 85.65 | |||||||
| Nandoskar et al. (2020) 21 | Royal Australasian College of Surgeons (Mission-based) | Indonesia, 2017 | Not listed | Both | Not listed | 704.6 | 4287.19 | 2186.47 | 42.87 |
*Both refers to both patients with isolated cleft lip and patients with isolated cleft palate. Abbreviations: GDP, gross domestic product; DALY, disability-adjusted life year, NGO, Non-Governmental Organization.