Table 3.
Cox proportional hazards models and a proportional hazards competing risk model of the risk of kidney failure according to baseline shunt parameter (ω0) computed for the log-normal + shunt model and the isoporous + shunt model
| Dextran sieving model | n * | HR (95% CI) | P |
|---|---|---|---|
| Log-normal + shunt model | |||
| Unadjusted | 185 | 1.96 (1.52, 2.52) | <0.0001 |
| Model 1 | 182 | 1.55 (1.17, 2.05) | 0.0024 |
| Model 2 | 182 | 1.46 (1.09, 1.95) | 0.0104 |
| Model 3 | 156 | 1.55 (1.13, 2.10) | 0.0058 |
| Competing risk† | 182 | 1.53 (1.20, 1.94) | 0.0006 |
| Isoporous + shunt model | |||
| Unadjusted | 185 | 2.47 (1.88, 3.24) | <0.0001 |
| Model 1 | 182 | 1.79 (1.30, 2.47) | 0.0004 |
| Model 2 | 182 | 1.69 (1.22, 2.35) | 0.0017 |
| Model 3 | 156 | 1.79 (1.25, 2.56) | 0.0014 |
| Competing risk† | 182 | 1.69 (1.32, 2.18) | <0.0001 |
The HRs and 95% CIs are expressed per 1-SD increment of ω0. Model 1 is adjusted for age, sex, MAP, HbA1c, GFR, and ACR. Model 2 is adjusted for model 1 covariates and diabetes duration. Model 3 is adjusted for model 1 covariates and PGLO and RA/RE ratio.
*
Number of participants with complete data for all covariates are shown for each model.
†
Sub-HR accounting for death as a competing risk is presented for a model adjusted for age, sex, MAP, HbA1c, GFR, and ACR.