TABLE 2.
Summary of the healing process in tendons.
Time (day) | Phase | Process |
---|---|---|
0–7 | Inflammatory stage | Blood cells accumulate, and blood clots form Pro‐inflammatory growth factors, which are released; Inflammatory cells are attracted, and fibroblasts are activated; The synthesis of the extracellular matrix begins; The migration and proliferation of the peripheral and intrinsic cells of the tendon begin; The synthesis of Collagen III collagen begins. |
8–42 | Multiplicative stage | More extracellular matrix, proteoglycans, and type III collagen are secreted; Tenocytes proliferate further; Water is absorbed in large amounts; the shift by Collagen from disorder to longitudinal direction begins. |
42+ | Remodelling stage | Extracellular matrix components are assembled into deposits of random tissues; Collagen is further arranged and cross‐linked; Type I collagen replaces Type III collagen; Cell numbers and the matrix begin to approach normal levels. |