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. 2023 Jun 8;20(9):3871–3883. doi: 10.1111/iwj.14261

TABLE 2.

Summary of the healing process in tendons.

Time (day) Phase Process
0–7 Inflammatory stage Blood cells accumulate, and blood clots form Pro‐inflammatory growth factors, which are released; Inflammatory cells are attracted, and fibroblasts are activated; The synthesis of the extracellular matrix begins; The migration and proliferation of the peripheral and intrinsic cells of the tendon begin; The synthesis of Collagen III collagen begins.
8–42 Multiplicative stage More extracellular matrix, proteoglycans, and type III collagen are secreted; Tenocytes proliferate further; Water is absorbed in large amounts; the shift by Collagen from disorder to longitudinal direction begins.
42+ Remodelling stage Extracellular matrix components are assembled into deposits of random tissues; Collagen is further arranged and cross‐linked; Type I collagen replaces Type III collagen; Cell numbers and the matrix begin to approach normal levels.