Table 2. Familial Risk of Bladder Cancer Among Offspring of Affected Parents.
| With affected parents |
Without affected parents | |||
|---|---|---|---|---|
| Father | Mother | Total | ||
| Number of people at risk | 33,244 | 4,473 | 37,760 | 5,486,643 |
| Male | 23,358 | 3,221 | 26,608 | 3,542,561 |
| Female | 9,886 | 1,252 | 11,152 | 1,944,082 |
| Number of cases | 25 | 4 | 29 | 1,283 |
| Person-years | 585,412 | 78,679 | 664,850 | 96,707,652 |
| Incidence/10,000 person-years (95% CI) | 0.43 (0.29 - 0.63) | 0.51 (0.19 - 1.35) | 0.44 (0.30 - 0.63) | 0.13 (0.13 - 0.14) |
| Crude HRs (95% CI) | 3.32 (2.21 - 4.97) | 2.02 (0.51 - 8.10) | 3.16 (2.14 - 4.66) | 1 |
| HRs (95% CI) adjusted for age and sex | 2.26 (1.51 - 3.39) | 1.10 (0.27 - 4.41) | 2.09 (1.41 - 3.08) | 1 |
| HRs (95% CI) adjusted for risk factorsa | 2.20 (1.47 - 3.30) | 1.09 (0.27 - 4.38) | 2.04 (1.38 - 3.01) | 1 |
aRisk factors include: age, sex, body mass index, blood pressure, cholesterol, fasting blood sugar, pulse pressure, proteinuria, drinking and smoking. HR: hazard ratio; CI: confidence interval.