Table 2.

Heritability Estimates of the Primary Endophenotypes and the Penn CNB Measures as Assessed in the Pedigrees

					Covariate P Valuea
Endophenotype	No.	h2 ± SE	95% CI	P Value	Age	Sex
PPIb	401	0.32 ± 0.13	0.06 to 0.57	.005	.04	< .001
P50 suppressionc	389	0.10 ± 0.18	−0.25 to 0.45	.18	.61	.67
Antisaccade task	525	0.42 ± 0.08	0.27 to 0.57	< .001	< .001	.93
CPTb	587	0.38 ± 0.07	0.23 to 0.52	< .001	< .001	.59
CVLTb	609	0.25 ± 0.08	0.11 to 0.40	< .001	< .001	< .001
LNSb	605	0.39 ± 0.07	0.25 to 0.52	< .001	< .001	.29
ABFb	543	0.28 ± 0.07	0.13 to 0.43	< .001	< .001	.73
FMEMb	533	0.27 ± 0.07	0.13 to 0.41	< .001	< .001	.25
SMEMb	520	0.24 ± 0.08	0.08 to 0.40	< .001	< .001	.45
SPAb	469	0.55 ± 0.08	0.39 to 0.71	< .001	< .001	< .001
S-Mb	521	0.39 ± 0.08	0.23 to 0.55	< .001	< .001	.007
EMOb	516	0.32 ± 0.07	0.18 to 0.46	< .001	< .001	.002

Abbreviations: ABF, Abstraction and Mental Flexibility; CI, confidence interval; CPT, Continuous Performance Test; CVLT, California Verbal Learning Test; EMO, Emotion Recognition; FMEM, Face Memory; ${\text{h}}_{\text{r}}^2$, residual heritability after variance due to covariates is removed; LNS, Letter-Number Sequencing test; Penn CNB, University of Pennsylvania Computerized Neurocognitive Battery; PPI, prepulse inhibition of the startle response; S-M, Sensorimotor Dexterity; SMEM, Spatial Memory; SPA, Spatial Processing.

^aNote that for each endophenotype, only significant covariates were accommodated in the heritability analysis.

^bSignificantly heritable endophenotypes (P < .05).

^cAn alternative measure of P50 suppression, the conditioning-test amplitude difference, was found to be significantly heritable (h² = 0.28 ± 0.11; P = .004) in this sample.