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Line graphs showing the four DTI-NAWM parameters change differences over time between pw-RRMS and HCs. BL: baseline; 2-YFU: 2-years follow-up; FA: fractional anisotropy; RD: radial diffusivity; AD: axial diffusivity; MD: mean diffusivity; NAWM: normal-appearing white matter; FA is unitless, while AD, MD and RD are in mm2/s.
