Table 3.
Top differentially expressed genes identified in erosive rheumatoid arthritis patients (n=26).
| Genes | Ave FC | FDR | Main biological process |
|---|---|---|---|
| Up-regulated genes | |||
| HSPA1B | 9.26 | < 0.0001 | Heat shock protein and ubiquitin-proteasome pathway. |
| HLA-DQA2 | 6.35 | 0.009525 | Adaptive immunity. |
| KLF14 | 4.6 | 0.041606 | Innate and adaptative immunity. |
| IL18RAP | 3.9 | 0.031739 | Cytokine activity. |
| CMTM1 | 3.83 | 0.043922 | Chemokine activity. |
| ST6GALNAC6 | 3.76 | 0.043904 | Sialyltransferase and alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. |
| ENSG00000260861 | 3.67 | 0.049279 | Unknown function. |
| ZNF665 | 3.64 | 0.019876 | Regulation of transcription by RNA polymerase II. |
| GSDMA | 3.54 | 0.039658 | Apoptotic process. |
| GPA33 | 3.30 | 0.046824 | Signaling receptor activity. |
| Down-regulated genes | |||
| NALF1 | 0.0018 | 0.02 | Calcium channel activity. |
| LARP6 | 0.0026 | < 0.0001 | Collagen biosynthetic. |
| PRRX1 | 0.0029 | 0.0004 | Regulation of transcription by RNA polymerase II. |
| RAB3B | 0.0061 | < 0.0001 | Regulation of ion transport. |
| AHNAK2 | 0.0065 | < 0.0001 | Wound healing. |
| PAPPA | 0.0072 | < 0.0001 | Bone formation, inflammation and wound healing. |
| RND3 | 0.0073 | < 0.0001 | Cortical cytoskeleton organization. |
| CPEB1 | 0.0083 | < 0.0001 | Negative regulation of cytoplasmic translation. |
| UCHL1 | 0.0085 | < 0.0001 | Ubiquitin-dependent protein catabolic process. |
| CDH13 | 0.0089 | 0.001 | Regulation of cell population proliferation. |
Genes were ranked according to the fold change. FC, Fold-change; Ave FC, average FC; FDR, False Discovery Rate.