Table 7:

Univariate and multivariate analysis in C3G patients with adult onset

	n	n.event	H.R.	95%C.I.	p-value
UNIVARIATE ANALYSIS
Male	101	35	0,52	0.26–1.1	0,069
eGFR<60ml/min/1.73m2	90	31	9,5	3.3–28	0,000037
nephrotic range proteinuria	85	29	1,26	0.59–2.7	0,55
Pu > 1.5/day	78	28	1,3	0.44–3.8	0,63
Immunosuppressors	78	29	0,795	0.36–1.7	0,57
C3NeF	99	33	0,614	0.29–1.3	0,2
rare/pathogenic variant	87	33	2,54	1.2–5.4	0,017
C3C5status : Low C3 High sC5b-9	101	35	1,94	0.63–6	0,25
C3C5status : Low C3 Normal sC5b-9	101	35	3,48	1.1–11	0,037
C3C5status : Normal C3 High sC5b-9	101	35	4,79	1.4–16	0,013
MULTIVARIATE ANALYSIS
eGFR<60ml/min/1.73m2	78	29	8.13	2.7–24	1.7e-04
C3C5 status: Low C3 High sC5b-9	78	29	3.91	0.95–16	0.06
C3C5 status: Low C3 Normal sC5b-9	78	29	9.42	2.1–42	3.3e-03
C3C5 status: Normal C3 High sC5b-9	78	29	5.47	1.3–23	0.02
rare/pathogenic variant	78	29	6.17	2.3–17	3.4e-04
Male	78	29	0.738	0.34–1.6	0.45

Abbreviations: eGFR, estimated glomerular filtration rate; Pu, proteinuria,

Nb, number of patients with available information, n.event, number of patients reaching ESKD, H.R, Hazard Ratio.