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NAFLD-Related Diseases and Risk Factors
| Major risk factors | Minor risk factors |
|---|---|
| Being overweight/obese | Hyperuricemia |
| Type 2 diabetes mellitus | Hypothyroidism |
| Insulin resistance | Intestinal microbiota dysbiosis |
| Hypertension | Sleep apnea syndrome |
| Metabolic syndrome | Polycystic ovary syndrome |
| Dyslipidemia | Genetic factors: PNPLA3, TM6SF2 |
| Epigenetic factors: DNA methylation, micro-RNA’s |
PNPLA3: Patatin-like phospholipase domain-containing protein; TM6SF2: Transmembrane 6 superfamily member 2.
