Table 3:

Clinical data and outcomes by Day 1 serum renin+prorenin concentration above or below the optimal threshold to predict severe persistent acute kidney injury.

Variable	Day 1 Renin+Prorenin <6769 pg/ml	Day 1 Renin+Prorenin >6769 pg/ml	p-value
N (% cohort)	178 (76)	55 (24)	--
Sex, n (% male)	88 (49)	21 (38)	0.14
Age, years	5.5 (1.8,9.6)	2.7 (0.8,9.0)	0.09
PRISM III	11 (8,15)	13 (8,18)	0.08
D1 Vasoactives, n (%)	161 (90)	52 (95)	0.34
D1 VIS	12.5 (5,28.8)	21 (10,42)	0.005
D1-7 Severe Persistent AKI, n (%)	17 (10)	25 (45)	RR 4.8 (2.8-8.1, p<0.001)
D1-7 KRT, n (%)	11 (6.2)	16 (29)	RR 4.7 (2.4-9.5, p<0.001)
7-Day Vasoactive-Free Days	5 (2.8,6)	3 (0,4)	<0.001
28-day PICU-Free Days	19 (10.8,23)	6 (0,20)	<0.001
28-Day Mortality, n (%)	12 (6.7)	20 (36)	RR 5.4 (2.8-10.3, p<0.001)

Continuous variables reported as median (IQR); RR- relative risk (95% confidence interval, p-value)

VIS-vasoactive-inotropic score; KRT- kidney replacement therapy; Severe Persistent AKI: ≥KDIGO stage 2 AKI present for >48h consecutively