Table 3.

Results of validation of the GENIE model in children with Crohn’s disease [CD] during treatment with 100% EN and after return to unrestricted diet and compared with the development cohort of healthy adults

GENIE models	Cohort	Sensitivity, %	Specificity, %	PPV, %	NPV, %
L-GENIE [IC5/C4 + IC4/C2]	Healthy adults	88	94	92	92
L-GENIE [IC5/C4 + IC4/C2]	Children with CD	50	96	93	65
C-GENIE [pH ≥ 8.0]	Healthy adults	84	86	81	89
C-GENIE [pH ≥ 8.0]	Children with CD	85	88	88	85

C2, acetate; C4, butyrate; CD, Crohn’s disease; C-GENIE, Clinical Glasgow Exclusive Enteral Nutrition Index of Compliance; GENIE, Glasgow Exclusive Enteral Nutrition Index of Compliance; IC4, isobutyrate; IC5, isovalerate; L-GENIE, Laboratory Glasgow Exclusive Enteral Nutrition Index of Compliance; NPV, negative predictive value; PPV, positive predictive value.