TABLE 2.
Cure rates for mice infected with T. cruzi Colombiana and treated with Bz and rIL-12a
| Experimental group | No. (%) of mice that survived (n = 15) | No. of mice in the
following groups with negative results by the indicated test:
|
|||
|---|---|---|---|---|---|
| Survivorsb
|
PCR
after negative hemoculture result
|
||||
| IIF | Hemo | Blood DNA | Heart DNA | ||
| Control (untreated) | 1 (6.6) | 0 | 0 | 0 | 0 |
| Bz | 15 (100.0)* | 2 | 3* | 3 | 2 |
| Bz + rIL-12 (100 ng/ml) | 13 (86.7)* | 9 | 9** | 9 | 7 |
| Bz + rIL-12 (250 ng/ml) | 5 (33.3)** | 5 | 5** | 5 | 5 |
a
* and **, results shown in the same column are statistically significant (P < 0.01).
b
IIF, indirect immunofluorescence (titer, ≥1:20); Hemo, hemoculture.