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. Author manuscript; available in PMC: 2023 Oct 20.
Published in final edited form as: Nat Med. 2022 Feb 3;28(2):383–391. doi: 10.1038/s41591-021-01660-8

Extended Data Fig. 4 |. H2HA-Ferritin vaccination induces broadly neutralizing antibodies in H2-naïve adults.

Extended Data Fig. 4 |

Sera from H2-naïve (blue circles) and H2-exposed (green circles) participants who received H2HA-Ferritin in either homologous (closed circles) or heterologous (open circles) prime-boost regimens were analyzed with a pseudotyped lentivirus neutralization assay. Individual results, group geometric means, and geometric mean fold increases over baseline are shown for A) H2N2 A/Singapore/1/57 and B) H5N1 A/Vietnam/1203/04. Whiskers indicate 95% confidence intervals. Dotted lines indicate the lower limit of detection, arrows indicate vaccination timepoints. Negative samples were reported and calculated as half the limit of detection. Number of participant sera analyzed at each time point is summarized in Supplementary Table 7.