Extended Data Fig. 5 |. Preexisting and vaccine-induced antibody titers against H2N2 virus compared to age.

The neutralizing antibody titers from the reporter microneutralization assay at two weeks after the boost (week 18) for H2-naïve (blue circles, n = 13) and H2-exposed (green circles, n = 9) participants that received two doses of H2HA-Ferritin were compared to the age of the participants at time of enrollment. Two-sided Spearman’s rank correlation coefficient (ρ) and p values for all age groups were ρ=0.39 and p = 0.064. For the H2-naïve adults only, the values were ρ=−0.52 and p = 0.072. For the H2-exposed adults only, the values were ρ=0.6 and p = 0.067.