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. Author manuscript; available in PMC: 2023 Oct 20.
Published in final edited form as: Nat Med. 2022 Feb 3;28(2):383–391. doi: 10.1038/s41591-021-01660-8

Fig. 6 |. The neutralizing H2HA-Ferritin vaccine-induced antibodies are directed against the HA stem.

Fig. 6 |

Sera from H2-naive (blue circles) and H2-exposed (green circles) participants who received H2HA-Ferritin in either homologous (closed circles) or heterologous (open circles) prime-boost regimens were evaluated by a competition microneutralization assay against heterologous H5N1 A/Vietnam/1203/04 virus at 2 weeks after the boost vaccination (week 18). Competing antigens include the full-length H2 HA, H2 HA stem and a negative control (DSCav-1). Lines represent group geometric means, and whiskers indicate 95% confidence intervals. Dotted lines indicate the lower limit of detection for the assay.