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. 2023 Oct 20;18(10):e0291880. doi: 10.1371/journal.pone.0291880

Fig 2. Nrf2 gene rescue in macrophages does not affect body mass and insulin tolerance.

Fig 2

(A) Time course of changes in the body mass of wild-type (WT) mice fed normal chow (NC), and WT, Nrf2-KO, and Nrf2-mRes mice fed a high-fat diet (HFD) and administrated lipopolysaccharide (LPS) from Porphyromonas gingivalis (P.g.) (WT NC; n = 7, WT HFD + LPS; n = 14, Nrf2-KO HFD + LPS; n = 9, Nrf2-mRes HFD + LPS; n = 14). (B) Weights of white adipose tissues around the testis (WAT), liver, and liver weight ratio to body weight (BW) in each group at 23 weeks of age (n = 7–14/group). (C) Changes in blood glucose concentration and area under the curve (AUC) during intraperitoneal glucose tolerance testing (ipGTT) in mice at 21 weeks of age (n = 7–14/group). (D) Changes in blood glucose concentration and AUC during intraperitoneal insulin tolerance testing (ipITT) in mice at 22 weeks of age (n = 7–14/group) mice. Values are the mean ± SEM. ‡P < 0.05, WT NC vs. HFD + LPS groups, *P < 0.05, WT HFD + LPS vs. Nrf2-KO HFD + LPS or Nrf2-mRes HFD + LPS.