Table 3.
Multivariable Analysis Showing Those Baseline Factors Independently Associated With Achievement of Deep Steroid-Free Remission at Week 14 (Infliximab and Vedolizumab) or Week 16 (Ustekinumab)
Baseline variable | Adjusted OR | 95% CI | P value |
---|---|---|---|
| |||
Previous exposure to a biologic | 3.49 | 1.43–8.53 | <.01a |
Age (OR per year) | 1.01 | 1.04–0.97 | .76 |
Visceral adipose tissue (OR per IA-VAT% of body mass) | 0.40 | 0.16–0.98 | .03a |
Total body fat (OR per % of body mass) | 0.97 | 0.92–0.98 | .19 |
Baseline C-reactive protein (OR per mg/dL) | 0.72 | 1.02–1.09 | .03a |
Baseline albumin (OR per g/dL) | 0.58 | 0.05–6.71 | .67 |
Drug level higher than the median within the populationbc | 2.97 | 1.20–7.32 | .02a |
Statistically significant.
Stratified by each drug group: infliximab, vedolizumab, and ustekinumab.
Median drug levels were 9.8, 11.1, and 4.9 mg/dL for infliximab, vedolizumab, and ustekinumab, respectively.