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. 2023 May 3;94(4):1317–1326. doi: 10.1038/s41390-023-02610-5

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© The Author(s) 2023

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Fig. 4 — a PCA of 1010 metabolites with <30% imputed values. PC1 accounts for 22% of the variance in metabolite abundance between HC-treated and untreated infants with the majority reduced by HC. b Box plot. Significance of PC1 (p = 8.3e–7) and not PC2 (p = 0.65) in PCA analysis. c Volcano plot. Significant differences (above dashed red line) with HC are primarily negative (left of 0) and include metabolites of all super pathways.