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. 2023 Oct 20;6(12):e202302073. doi: 10.26508/lsa.202302073

Figure 3. Key players of eye development are altered in Tmem107−/− animals at E10.5–E11.5.

Figure 3.

(A, A’’, A’’, B, B’, B’’, C, C’, C’’, D, D’, D’’, E, E’, E’’, F, F’, F’’, G, G’, G’’, H, H’, H’’, I, I’, I’’, J, J’, J’’, K, K’, K’’, L, L’, L’’) Immunohistochemical detection of PAX6 (A, A’, A’’, B, B’, B’’, G, G’, G’’, H, H’, H’’), PAX2 (C, C’, C’’, D, D’, D’’, I, I’, I’’, J, J’, J’’), and SOX1 (E, E’, E’’, F, F’, F’’, K, K’, K’’, L, L’, L’’) proteins in individual eye structures in E10.5 and E11.5 embryos. (A, A’’, A’’, B, B’, B’’, C, C’, C’’, D, D’, D’’, E, E’, E’’, F, F’, F’’, G, G’, G’’, H, H’, H’’, I, I’, I’’, J, J’, J’’, K, K’, K’’, L, L’, L’’) PAX6 (red) expression in the neural retina, lens, pigment epithelium, and optic stalk in WT (A, A’, A‘‘, G, G’, G‘‘) in comparison with Tmem107−/− animals (B, B’, B’’, H, H’, H’’). PAX2 (red) expression in optic stalk and distal part of neural retina in WT (C, C’, C’’, I, I’, I’’) in comparison with Tmem107−/− animals (D, D’, D’’, J, J’, J’’). SOX1 (red) expression in lens vesicle of WT (E, E’, E’’) was higher in contrast with Tmem107−/− (F, F’, F’’) similar as in E11.5 WT (K, K’, K’’) in comparison with Tmem107−/− mutants (L, L’, L’’). Nuclei are counterstained with DAPI. NR, neural retina; RPE, retinal pigment epithelium; OS, optic stalk. Scale bar = 200 μm.