Table 2.

Grade ≥ 3 adverse events according to the severity of creatinine clearance.

	Normal		Mild		Moderate to severe		P value (vs normal)
	n	%	n	%	n	%	Mild	Moderate to severe
Any hematologic AE	38	(31)	53	(41)	31	(56)	0.09	0.001
Neutropenia	30	(24)	44	(34)	29	(53)	0.09	< 0.001
Anemia	8	(7)	14	(11)	11	(20)	0.22	0.007
Thrombocytopenia	4	(3)	4	(3)	1	(2)	0.95	0.6
Any nonhematologic AE	12	(10)	17	(13)	11	(20)	0.39	0.057
Fatigue	3	(2)	2	(2)	2	(3)	0.61	0.65
Anorexia	6	(5)	7	(5)	5	(9)	0.84	0.27
Diarrhea	1	(1)	1	(1)	1	(2)	0.97	0.55
Stomatitis	0	(0)	0	(0)	0	(0)	NA	NA
Infection	0	(0)	0	(0)	0	(0)	NA	NA
Febrile Neutropenia	1	(1)	4	(3)	4	(7)	0.19	0.015
Nausea	0	(0)	1	(1)	0	(0)	0.33	NA
Liver dysfunction	1	(1)	0	(0)	0	(0)	0.31	0.5
Interstitial pneumonia	0	(0)	0	(0)	0	(0)	NA	NA
Skin disorders	0	(0)	0	(0)	1	(2)	NA	0.13

AE, adverse event; NA, not available.