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. 2023 Oct 20;14:6638. doi: 10.1038/s41467-023-42456-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The specific activity of mLDHD to convert D-lactate (D-LAC) to pyruvate (PYR) in the absence and presence of different divalent metal ions (1 mM). b The specific activity of mLDHD towards D-LAC under different pH. c The saturation curve of mLDHD towards D-LAC. d The specific activity of mLDHD towards different substrates and analogs (1 mM). For the racemic substrates, the substrate concentration used in the experiment was doubled and the specific activity was calculated based on the corrected concentration of D-isomer (1/2 of the concentration of racemic substrate). Data are presented as the mean ± SEM (n = 3 independent measurements). Source data are provided as a Source Data file. D-LAC D-lactate, L-LAC L-lactate, GLC glycolate, D-MAL D-malate, D-2-HG D-2-hydroxyglutarate, DL-2-HAP DL-2-hydroxy-3-aminopropionate, D-2-HB D-2-hydroxybutyrate, DL-2-HV DL-2-hydroxyvalerate, DL-2-HH DL-2-hydroxyhexanoate, DL-2-HO DL-2-hydroxyocatanoate, D-2-HIV D-2-hydroxyisovalerate, DL-2-HIC DL-2-hydroxycaproate, DL-2-HMV DL-2-hydroxy-3-methylvalerate, D-2-HPP D-2-hydroxy-3-phenylpropionate, and DL-3-HB DL-3-hydroxybutyrate.