Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Oct 20;14:6639. doi: 10.1038/s41467-023-42428-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — Zeb1 deficiency in dendritic cells leads to a selective reduction of splenic cDC1, associated with excessive cell death, rendering mice more resistant to Listeria infection. Additionally, cDC1 from other sources of Zeb1-deficient mice display impaired cross-presentation of exogenous antigens, compromising antitumor CD8⁺ T cell responses. Mechanistically, Zeb1 facilitates the production of phagosomal reactive oxygen species (ROS) by repressing the expression of microRNA-96/182 that targeted Cybb mRNA of NADPH oxidase Nox2. Consequently, loss of Zeb1 in cDC1 diminishes phagosomal ROS and subsequent phagosomal membrane rupture that allows antigen export to the cytosol.