Fig. 1. Antigenic characterization of SARS-CoV-2 antibody responses in urban and indigenous children.

IgG responses of sera samples collected in March and April 2021 were measured using MULTICOV-AB towards the spike B.1 (a), the RBD B.1 (b), the S1 B.1 subdomain (c), the S2 B.1 subdomain (d), and the nucleocapsid B.1 antigen (e) of SARS-CoV-2. Data is expressed as normalized MFI ratio for seropositive urban children (n = 17, blue) and seropositive indigenous children (n = 28, yellow). Seropositivity is defined as a dual cut-off of spike and RBD S/CO ≥ 1.0. Boxes represent the median and the 25th and 75th percentiles. Whiskers show the largest and smallest non-outliers values. Outliers were identified using upper/lower quartiles 1.5 ± times IQR. Means of two population groups were compared with the Wilcoxon’s ranked sum test. Statistical significance was defined as p < 0.05.