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. 2023 Oct 20;14:6658. doi: 10.1038/s41467-023-42393-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Pictures of Glycyrrhiza uralensis plant and the Chinese herbal medicine Gan-Cao. b LC/MS analysis of the roots, cortexes, and leaves of G. uralensis, showing extracted ion chromatograms (XICs) of 1, 2, 1a and 2a. c The proposed biosynthetic pathway of 1a and 2a. CHS, chalcone synthase; CHR, chalcone reductase; CHI, chalcone isomerase. d Co-expression analysis of G. uralensis transcriptomes using GuCHS and GuCHR as bait genes. The circle of dots represents genes co-expressed with GuCHS and GuCHR. e Expression levels of candidate genes in the transcriptomes of different plant parts of G. uralensis. Two replicates were tested for each part (n = 2).