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. 2023 Oct 20;14:6669. doi: 10.1038/s41467-023-42371-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A MRI showing the most frequent tumor locations according to molecular subgroups. The round size indicates the number of tumors. The last column represents the tumors located on the midline, which are not additional cases, except the spinal MYC tumors. The different colors correspond to the molecular subgroups based on DNA methylation data (DKFZ brain tumor classifier v11b4): MYC (green), TYR (red) and SHH (blue). B Bar plot showing the distribution of the different molecular groups assigned according to the DNA methylation profile at the supra- and infratentorial level. C Pie charts showing the distribution of the different ATRT anatomical locations at infra and supratentorial levels. NA: not available anatomical location. The color code is referred to at the bottom of Fig. 1. MCP/ICV: middle cerebellar peduncle and inferior cerebellar vermis. D UMAP analysis performed on human ATRT DNA methylation array data. E Unsupervised hierarchical clustering of ATRT samples based on DNA methylation data. Top annotation indicates ATRT anatomical location and molecular subgroup. Source data are provided as a Source Data file.