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. 2023 Oct 20;14:6669. doi: 10.1038/s41467-023-42371-7

Fig. 2. Integrative analysis identified four anatomical-molecular subgroups and splits SHH ATRT in two subgroups with distinct anatomical locations and transcriptional profiles.

Fig. 2

A Unsupervised hierarchical clustering of human ATRT samples based on RNAseq dataset. Anatomic location as well as the assigned RNAseq subgroup for each sample is indicated in the top annotations. B, C Consensus clustering of human ATRT samples based on RNAseq data with k = 3 (B) and k = 4 (C). D UMAP of human ATRT based on the integrated DNA methylation and transcriptomics datasets (kernel-based approach). Points indicate tumor samples, colors indicate anatomic location and the ellipses indicate tumor anatomical-molecular subgroups. E sPLS-DA individual plot using the two major components (comp, comp 1, and comp3). Points indicate tumor samples, colors indicate anatomic location and the ellipses indicate tumor anatomical-molecular subgroups. sPLS-DA was applied on RNAseq data. Source data are provided as a Source Data file.