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. 2023 Oct 20;14:6669. doi: 10.1038/s41467-023-42371-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Unsupervised hierarchical clustering of mouse RT (n = 21 biologically independent mice) based on transcriptomic dataset of combined RNAseq dataset (n = 16 biologically independent samples, sample name colored in black) and gene expression microarray dataset (n = 8 biologically independent samples, sample name colored in green). 3 samples (bold sample names) were processed using the two platforms and used to control the cross-platform data integration. B Anatomical distribution of Rosa26::CreERT2/Smarcb1flox/flox (R26) RT; circles correspond to Tamoxifen injection at E6-E7 while squares correspond to E8-E10; gray indicates intra-CNS tumors, blue, indicates extra-CNS tumors. C Hematoxylin Eosin Safran (HES, a, c) and BAF47 staining (b, d) of sagital (a, b) and coronal (c, d) sections of brains from the R26 mice. Red arrows point to intra-CNS tumors (a, b); green arrows point to extra-CNS tumors (c, d). Scale bars: 1 mm (D) Single sample gene set enrichment analysis of murine RT samples based on RNAseq data (n = 16). Each dot corresponds to one sample; sample names are colored according to molecular subgroups (black: Shh; blue: Myc). Average enrichment scores (in percentage) of the top 5 differentially enriched neuronal development-related (red) and immune-related (blue) gene sets are considered and indicated for each sample. Source data are provided as a Source Data file.