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. 2023 Oct 20;9:85. doi: 10.1038/s41523-023-00588-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A The sensitivity of several TNBC cell lines was confirmed by the CCK-8 assay. B Treatment of Olaparib induced the upregulation of BRCA1. C The sensitivity of HCC1806 to Olaparib after transfecting exogenous BRCA1 was detected by CCK-8. D TRIM21^OE and TRIM21^KO TNBC cell lines possess different sensitivity toward Olaparib. A, C, and D Data are shown as the mean ± SD of at least three independent experiments. E Correlation analysis between the TRIM21 expression level and IC₅₀ to Olaparib of various breast cancer cell lines. P = 0.0019. F, G MDA-MB-231 TRIM21^KO and TRIM21^WT cells (1 × 10⁶ cells/mouse) were injected into the right fourth breast pad. The mice were randomly divided into four groups with different setups. Tumor volumes were measured every 3 days. Data were shown as mean ± SD. The significant level was identified by *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001. Two-way ANOVA analysis is used for all cell viability curves (A, C and D) and tumor growth curves (G).